| Abstract | The steady state and time-resolved fluorescence study of 2-amino-5,6-dimethyl-benzimidazole (ADBI) have been studied in aqueous
solution of -cyclodextrin (-CD). The fluorescence decays were analyzed by global analysis and distribution analysis in order to get insight
about the inclusion process. The fluorescence lifetime of ADBI is increased in -CD and an enhancement of the emission, is observed, together
with negligible changes in the energy of ADBI in -CD. The experimental data show that -CD reacts with ADBI to form a 1:1 host–guest
complex with association constant was determined to be 2074 ± 77M?1. Both global analysis and distribution analysis of the fluorescence
decays support the formation of only 1:1 inclusion complex. AM1 calculation shows that the size of ADBI was appropriate for good insertion
within the -CD cavity and the inclusion of ADBI inside the -CD cavity should takes place from the side of the amino group substituent.
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